2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-5-C3-NH2 hydrochloride

Pomalidomide-5-C3-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.

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Pomalidomide-5-C3-NH2 hydrochloride Chemical Structure

Pomalidomide-5-C3-NH2 hydrochloride Chemical Structure

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Pomalidomide-5-C3-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Pomalidomide-5-C3-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].

Molecular Weight

366.80

Formula

C16H19ClN4O4
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C=CC(NCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
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Pomalidomide-5-C3-NH2 hydrochloride Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-5-C3-NH2E3 Ligase Ligand-Linker ConjugatesCRBNPomalidomidePROTACInhibitorinhibitorinhibit

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Pomalidomide-5-C3-NH2 hydrochloride
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