2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-C5-azide

Pomalidomide-C5-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand-Linker conjugate. The azide group can undergo a click chemical reaction.

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Pomalidomide-C5-azide Chemical Structure

Pomalidomide-C5-azide Chemical Structure

CAS No. : 2434629-02-2

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5 mg USD 540 In-stock
10 mg USD 860 In-stock
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Based on 1 publication(s) in Google Scholar

Pomalidomide-C5-azide Related Antibodies

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Description

Pomalidomide-C5-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand-Linker conjugate. The azide group can undergo a click chemical reaction[1].

Molecular Weight

384.39

Formula

C18H20N6O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCN=[N+]=[N-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6015 mL 13.0076 mL 26.0152 mL
5 mM 0.5203 mL 2.6015 mL 5.2030 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6015 mL 13.0076 mL 26.0152 mL 65.0381 mL
5 mM 0.5203 mL 2.6015 mL 5.2030 mL 13.0076 mL
10 mM 0.2602 mL 1.3008 mL 2.6015 mL 6.5038 mL
15 mM 0.1734 mL 0.8672 mL 1.7343 mL 4.3359 mL
20 mM 0.1301 mL 0.6504 mL 1.3008 mL 3.2519 mL
25 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6015 mL
30 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1679 mL
40 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6260 mL
50 mM 0.0520 mL 0.2602 mL 0.5203 mL 1.3008 mL
60 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0840 mL
80 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8130 mL
100 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6504 mL
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Pomalidomide-C5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C5-azide2434629-02-2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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