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  4. Pomalidomide-NH-PEG6-amide-C2-CPI-1612

Pomalidomide-NH-PEG6-amide-C2-CPI-1612 (compound 22 (dCE-1)) is a CBP/EP300 degrader, which contains a CRBN ligands Pomalidomide, a 24-atom linker with 6 PEG units and a HAT inhibitor CPI-1612. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 exhibits antiproliferative effects in cells multiple myeloma cells LP1 (with a DC50 of 1.2 μM), MM1S and various cancer cell lines, especially the leukemia cells.

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Pomalidomide-NH-PEG6-amide-C2-CPI-1612 Chemical Structure

Pomalidomide-NH-PEG6-amide-C2-CPI-1612 Chemical Structure

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Pomalidomide-NH-PEG6-amide-C2-CPI-1612 Related Antibodies

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Description

Pomalidomide-NH-PEG6-amide-C2-CPI-1612 (compound 22 (dCE-1)) is a CBP/EP300 degrader, which contains a CRBN ligands Pomalidomide, a 24-atom linker with 6 PEG units and a HAT inhibitor CPI-1612. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 exhibits antiproliferative effects in cells multiple myeloma cells LP1 (with a DC50 of 1.2 μM), MM1S and various cancer cell lines, especially the leukemia cells[1].

Molecular Weight

1085.21

Formula

C57H68N10O12
SMILES

O=C(N(C(C(N1)=O)CCC1=O)C2=O)C3=C2C(NCCOCCOCCOCCOCCOCCOCCNC(CCCN4N=CC(C5=CC=C(NC([C@@H](C6=CC=CC=C6)NC[C@@H](C)C7=CC=C(C#N)C=C7)=O)N=C5)=C4)=O)=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pomalidomide-NH-PEG6-amide-C2-CPI-1612 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-NH-PEG6-amide-C2-CPI-1612PROTACsCREB-binding proteinE1A-associated proteinLP1MM1Smultiple myeloma 1SleukemiaInhibitorinhibitorinhibit

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