Pomalidomide-PEG1-azide

Cat. No.: HY-133138 Purity: 95.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131). Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Pomalidomide-PEG1-azide Chemical Structure

CAS No. : 2133360-04-8

Size	Price	Stock	Quantity
5 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131)^[1]. Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

400.35

Formula

C₁₇H₁₆N₆O₆

CAS No.

2133360-04-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4978 mL	12.4891 mL	24.9781 mL
5 mM	0.4996 mL	2.4978 mL	4.9956 mL
10 mM	0.2498 mL	1.2489 mL	2.4978 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.19%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (280 KB) LCMS (262 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4978 mL	12.4891 mL	24.9781 mL	62.4454 mL
	5 mM	0.4996 mL	2.4978 mL	4.9956 mL	12.4891 mL
	10 mM	0.2498 mL	1.2489 mL	2.4978 mL	6.2445 mL
	15 mM	0.1665 mL	0.8326 mL	1.6652 mL	4.1630 mL
	20 mM	0.1249 mL	0.6245 mL	1.2489 mL	3.1223 mL
	25 mM	0.0999 mL	0.4996 mL	0.9991 mL	2.4978 mL
	30 mM	0.0833 mL	0.4163 mL	0.8326 mL	2.0815 mL
	40 mM	0.0624 mL	0.3122 mL	0.6245 mL	1.5611 mL
	50 mM	0.0500 mL	0.2498 mL	0.4996 mL	1.2489 mL
	60 mM	0.0416 mL	0.2082 mL	0.4163 mL	1.0408 mL
	80 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7806 mL
	100 mM	0.0250 mL	0.1249 mL	0.2498 mL	0.6245 mL