2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Poneratoxin

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.6 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.

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Poneratoxin Chemical Structure

Poneratoxin Chemical Structure

CAS No. : 137084-94-7

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Poneratoxin Related Antibodies

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  • Biological Activity

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Description

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.6 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals[1].

In Vivo

Poneratoxin causes immediate and long-lasting nocifensive behaviours (20 to 600 pmol, intraplantar injection, single dose) in C57BL/6 J mice model, and leads to paralysis with PD50 (1 h) of 74.3 nmol/g in blowflies model (0-100 nmol/g, ip, single dose)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice model[1]
Dosage: 20 to 600 pmol
Administration: intraplantar injection, single dose
Result: Caused spontaneous nocifensive behaviours.
Animal Model: blowflies model[1]
Dosage: 0-100 nmol/g
Administration: Ip, single dose
Result: Caused paralysis.
Molecular Weight

2756.35

Formula

C129H215N33O31S
CAS No.
Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Sequence Shortening

FLPLLILGSLLMTPPVIQAIHDAQR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Poneratoxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poneratoxin137084-94-7Sodium ChannelNa channelsNa+ channelsParaponera clavataC57BL/6J miceHEK293Inhibitorinhibitorinhibit

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