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  3. Poricoic acid G

Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans.

For research use only. We do not sell to patients.

Poricoic acid G Chemical Structure

Poricoic acid G Chemical Structure

CAS No. : 415724-84-4

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Description

Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 3a
Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
AZ-521 cell line IC50
> 100 μM
Compound: 3a
Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
DU-145 IC50
> 100 μM
Compound: 3a
Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
HL-60 IC50
32.6 μM
Compound: 3a
Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
HL-60 IC50
32.6 μM
Compound: 14
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 19746919]
HL-60 GI50
39.3 nM
Compound: 1, poricoic acid G
Growth inhibition of human HL60 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HL60 cells after 48 hrs by sulforhodamine B assay
[PMID: 11975480]
OVCAR-3 IC50
> 100 μM
Compound: 3a
Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
PANC-1 IC50
> 100 μM
Compound: 3a
Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
SK-BR-3 IC50
> 100 μM
Compound: 3a
Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21250700]
Molecular Weight

486.68

Formula

C30H46O5

CAS No.
SMILES

C/C(C)=C\CC[C@@H](C(O)=O)[C@H]1[C@H](O)C[C@]2(C)[C@]1(C)CCC3=C2CC[C@@H](C(C)=C)[C@@]3(CCC(O)=O)C

Structure Classification
Initial Source

Poria cocos

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Poricoic acid G
Cat. No.:
HY-N10071
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