2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Pozanicline

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction.

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Pozanicline Chemical Structure

Pozanicline Chemical Structure

CAS No. : 161417-03-4

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Pozanicline Related Antibodies

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Description

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].

IC50 & Target

Ki: 16 nM (α4β2* nAChR)[1]
Cellular Effect
Cell Line Type Value Description References
IMR-32 EC50
150 μM
Compound: S-4 (ABT-089)
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
[PMID: 9022806]
Clinical Trial
Molecular Weight

192.26

Formula

C11H16N2O
CAS No.
SMILES

CC1=C(OC[C@H]2NCCC2)C=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pozanicline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pozanicline161417-03-4ABT-089ABT089ABT 089nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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