PqsR-IN-1

Cat. No.: HY-146705: FAQs
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PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity.

For research use only. We do not sell to patients.

PqsR-IN-1 Chemical Structure

CAS No. : 1333636-58-0

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Description

PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity^[1].

IC₅₀ & Target

PqsR^[1]

In Vitro

PqsR-IN-1 (Compound 18) inhibits pqs system with IC₅₀ values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively^[1].
PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC₅₀ value in P. aeruginosa strain PAO1-L^[1].
PqsR-IN-1 (0-100 µM, 16 h) shows no significant toxicity to A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	A549 lung epithelial cells
Concentration:	0.1, 1, 12.5, 25, 50, and 100 µM
Incubation Time:	16 h
Result:	Showed no significant toxicity.

Molecular Weight

347.86

Formula

C₁₇H₁₈ClN₃OS

CAS No.

1333636-58-0

SMILES

CCCCCC1=NC(CN2C=NC3=CC=C(C=C3C2=O)Cl)=CS1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Scott Grossman, et al. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur J Med Chem. 2020 Dec 15;208:112778. [Content Brief]

PqsR-IN-1 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PqsR-IN-11333636-58-0BacterialLow cytotoxicityPyocyaninPAO1-LPA14Inhibitorinhibitorinhibit

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