2. Anti-infection
  3. Bacterial Antibiotic
  4. PqsR/LasR-IN-2

PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM.

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PqsR/LasR-IN-2 Chemical Structure

PqsR/LasR-IN-2 Chemical Structure

CAS No. : 2071705-93-4

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Based on 1 publication(s) in Google Scholar

PqsR/LasR-IN-2 Related Antibodies

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Description

PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM[1].

Molecular Weight

398.89

Formula

C21H23ClN4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCC(C1=CC=C(C=C1)OCCOC2=CC=C(C=C2/C=N/N3C=NN=C3)Cl)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (250.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5070 mL 12.5348 mL 25.0696 mL
5 mM 0.5014 mL 2.5070 mL 5.0139 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5070 mL 12.5348 mL 25.0696 mL 62.6739 mL
5 mM 0.5014 mL 2.5070 mL 5.0139 mL 12.5348 mL
10 mM 0.2507 mL 1.2535 mL 2.5070 mL 6.2674 mL
15 mM 0.1671 mL 0.8357 mL 1.6713 mL 4.1783 mL
20 mM 0.1253 mL 0.6267 mL 1.2535 mL 3.1337 mL
25 mM 0.1003 mL 0.5014 mL 1.0028 mL 2.5070 mL
30 mM 0.0836 mL 0.4178 mL 0.8357 mL 2.0891 mL
40 mM 0.0627 mL 0.3134 mL 0.6267 mL 1.5668 mL
50 mM 0.0501 mL 0.2507 mL 0.5014 mL 1.2535 mL
60 mM 0.0418 mL 0.2089 mL 0.4178 mL 1.0446 mL
80 mM 0.0313 mL 0.1567 mL 0.3134 mL 0.7834 mL
100 mM 0.0251 mL 0.1253 mL 0.2507 mL 0.6267 mL
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PqsR/LasR-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PqsR/LasR-IN-22071705-93-4BacterialAntibioticAnti-virulenceP. aeruginosaCiprofloxacinPqsRLasRhERG Inhibitorinhibitorinhibit

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