1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Primidone-d5

Primidone-d5 is the deuterium labeled Primidone. Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders[1].

For research use only. We do not sell to patients.

Primidone-d<sub>5</sub> Chemical Structure

Primidone-d5 Chemical Structure

CAS No. : 73738-06-4

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1 mg USD 300 In-stock
5 mg USD 920 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Primidone-d5 is the deuterium labeled Primidone. Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.28

Formula

C12H9D5N2O2

CAS No.
Unlabeled CAS

125-33-7

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C([2H])([2H])C1(C2=CC=CC=C2)C(NCNC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (223.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (223.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 0.67 mg/mL (3.00 mM)

H2O : ≥ 0.67 mg/mL (3.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4787 mL 22.3934 mL 44.7868 mL
5 mM 0.8957 mL 4.4787 mL 8.9574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 4.4787 mL 22.3934 mL 44.7868 mL 111.9670 mL
DMSO / DMSO 5 mM 0.8957 mL 4.4787 mL 8.9574 mL 22.3934 mL
10 mM 0.4479 mL 2.2393 mL 4.4787 mL 11.1967 mL
15 mM 0.2986 mL 1.4929 mL 2.9858 mL 7.4645 mL
20 mM 0.2239 mL 1.1197 mL 2.2393 mL 5.5984 mL
25 mM 0.1791 mL 0.8957 mL 1.7915 mL 4.4787 mL
30 mM 0.1493 mL 0.7464 mL 1.4929 mL 3.7322 mL
40 mM 0.1120 mL 0.5598 mL 1.1197 mL 2.7992 mL
50 mM 0.0896 mL 0.4479 mL 0.8957 mL 2.2393 mL
60 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8661 mL
80 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3996 mL
100 mM 0.0448 mL 0.2239 mL 0.4479 mL 1.1197 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Primidone-d5
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HY-B0339S
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