2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. (Pro34)-Peptide YY (human)

(Pro34)-Peptide YY (human) is a highly Y1-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

For research use only. We do not sell to patients.

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(Pro34)-Peptide YY (human) Chemical Structure

(Pro34)-Peptide YY (human) Chemical Structure

CAS No. : 179986-93-7

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(Pro34)-Peptide YY (human) Related Antibodies

Top Publications Citing Use of Products

View All Neuropeptide Y Receptor Isoform Specific Products:

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(Pro34)-Peptide YY (human) is a highly Y1-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors[1].

IC50 & Target[1]

NPY Y1 receptor

 

In Vitro

(Pro34)-Peptide YY (human) competes for all specific [125I]neuropeptide Y binding sites in intact SK-N-MC and HEL cells (Y1-like subtype) and in porcine splenic membranes (Y2-like subtype) with steep and monophasic curves. The affinity of (Pro34)-Peptide YY in intact SK-N-MC and HEL cells (pKi 7.8 ± 0.2 and pKi 8.2 ± 0.1, respectively) is quite similar to that of Peptide YY (pKi 8.5 ± 0.1 and pKi 8.6 ± 0.1, respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Pro34)-Peptide YY (human) Related Antibodies
Molecular Weight

4278.73

Formula

C194H294N54O56
CAS No.
Sequence Shortening

YPIKPEAPGEDASPEELNRYYASLRHYLNLVTRPRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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(Pro34)-Peptide YY (human) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Pro34)-Peptide YY (human)179986-93-7Neuropeptide Y ReceptorNPY receptorSK-N-MCPeptide YYHELInhibitorinhibitorinhibit

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(Pro34)-Peptide YY (human)
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