2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Propanidid

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure.

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Propanidid Chemical Structure

Propanidid Chemical Structure

CAS No. : 1421-14-3

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Propanidid Related Antibodies

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Description

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure[1][2].

IC50 & Target

GABAA receptor[1]
In Vivo

Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult cats (immobilized by D-tubocurarine)[3]
Dosage: 3-5 mg/kg
Administration: Injected into the femoral vein; single dosage
Result: A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.
The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.
The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.
Molecular Weight

337.41

Formula

C18H27NO5
CAS No.
SMILES

O=C(CC1=CC=C(C(OC)=C1)OCC(N(CC)CC)=O)OCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Propanidid Related Classifications

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Keywords:

Propanidid1421-14-3Sombrevin FabantolGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAanestheticarterial pressureInhibitorinhibitorinhibit

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