1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. Propanidid

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure.

For research use only. We do not sell to patients.

Propanidid Chemical Structure

Propanidid Chemical Structure

CAS No. : 1421-14-3

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Description

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure[1][2].

IC50 & Target

GABAA receptor[1]

In Vivo

Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult cats (immobilized by D-tubocurarine)[3]
Dosage: 3-5 mg/kg
Administration: Injected into the femoral vein; single dosage
Result: A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.
The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.
The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.
Molecular Weight

337.41

Formula

C18H27NO5

CAS No.
SMILES

O=C(CC1=CC=C(C(OC)=C1)OCC(N(CC)CC)=O)OCCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Propanidid
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HY-116457
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