Propargyl-PEG1-acid

Name: Propargyl-PEG1-acid
Brand: MedChemExpress
SKU: HY-130504
Rating: 4.5 (1 reviews)

Cat. No.: HY-130504 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG1-acid Chemical Structure

CAS No. : 55683-37-9

Size	Price	Stock	Quantity
250 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 99	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Propargyl-PEG1-acid

•Biochem Biophys Res Commun. 21 July 2022.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM^[1]. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

128.13

Formula

C₆H₈O₃

CAS No.

55683-37-9

Appearance

Liquid (Density: 1.140 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (390.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8046 mL	39.0229 mL	78.0457 mL
5 mM	1.5609 mL	7.8046 mL	15.6091 mL
10 mM	0.7805 mL	3.9023 mL	7.8046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (243 KB) HNMR (108 KB) MS (157 KB)

Handling Instructions (2659 KB)

References

[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.8046 mL	39.0229 mL	78.0457 mL	195.1143 mL
	5 mM	1.5609 mL	7.8046 mL	15.6091 mL	39.0229 mL
	10 mM	0.7805 mL	3.9023 mL	7.8046 mL	19.5114 mL
	15 mM	0.5203 mL	2.6015 mL	5.2030 mL	13.0076 mL
	20 mM	0.3902 mL	1.9511 mL	3.9023 mL	9.7557 mL
	25 mM	0.3122 mL	1.5609 mL	3.1218 mL	7.8046 mL
	30 mM	0.2602 mL	1.3008 mL	2.6015 mL	6.5038 mL
	40 mM	0.1951 mL	0.9756 mL	1.9511 mL	4.8779 mL
	50 mM	0.1561 mL	0.7805 mL	1.5609 mL	3.9023 mL
	60 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2519 mL
	80 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4389 mL
	100 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9511 mL