2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Propargyl-PEG1-SS-PEG1-acid

Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propargyl-PEG1-SS-PEG1-acid Chemical Structure

Propargyl-PEG1-SS-PEG1-acid Chemical Structure

CAS No. : 1807503-85-0

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Propargyl-PEG1-SS-PEG1-acid Related Antibodies

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Description

Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG1-SS-PEG1-acid Related Antibodies
Molecular Weight

264.36

Formula

C10H16O4S2
CAS No.
Appearance

Viscous Liquid

Color

Light yellow to yellow

SMILES

O=C(O)CCOCCSSCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

COA (241 KB) HNMR (111 KB)

Handling Instructions (2659 KB)
References
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Propargyl-PEG1-SS-PEG1-acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG1-SS-PEG1-acid1807503-85-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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HY-140109
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