2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG2-Tos

Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG2-Tos Chemical Structure

Propargyl-PEG2-Tos Chemical Structure

CAS No. : 145916-41-2

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Propargyl-PEG2-Tos Related Antibodies

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Description

Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG2-Tos Related Antibodies
Molecular Weight

254.30

Formula

C12H14O4S
CAS No.
Appearance

Liquid (Density: 1.210±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

C#CCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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Propargyl-PEG2-Tos Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG2-Tos145916-41-2PROTAC LinkersInhibitorinhibitorinhibit

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