2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG4-acid

Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG4-acid Chemical Structure

Propargyl-PEG4-acid Chemical Structure

CAS No. : 1415800-32-6

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500 mg USD 25 In-stock
1 g USD 43 In-stock
5 g USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

Propargyl-PEG4-acid Related Antibodies

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Description

Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

BTK-IAP PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of IAP E3 ligases family recruitment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG4-acid Related Antibodies
Molecular Weight

260.28

Formula

C12H20O6
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (192.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8420 mL 19.2101 mL 38.4202 mL
5 mM 0.7684 mL 3.8420 mL 7.6840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (240 KB) HNMR (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8420 mL 19.2101 mL 38.4202 mL 96.0504 mL
5 mM 0.7684 mL 3.8420 mL 7.6840 mL 19.2101 mL
10 mM 0.3842 mL 1.9210 mL 3.8420 mL 9.6050 mL
15 mM 0.2561 mL 1.2807 mL 2.5613 mL 6.4034 mL
20 mM 0.1921 mL 0.9605 mL 1.9210 mL 4.8025 mL
25 mM 0.1537 mL 0.7684 mL 1.5368 mL 3.8420 mL
30 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2017 mL
40 mM 0.0961 mL 0.4803 mL 0.9605 mL 2.4013 mL
50 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.9210 mL
60 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
80 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2006 mL
100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9605 mL
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Propargyl-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-acid1415800-32-6PROTAC LinkersInhibitorinhibitorinhibit

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