2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG4-alcohol

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propargyl-PEG4-alcohol Chemical Structure

Propargyl-PEG4-alcohol Chemical Structure

CAS No. : 87450-10-0

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Based on 1 publication(s) in Google Scholar

Propargyl-PEG4-alcohol Related Antibodies

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Description

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG4-alcohol Related Antibodies
Molecular Weight

232.27

Formula

C11H20O5
CAS No.
Appearance

Liquid (Density: 1.071±0.06 g/cm3)

Color

Light yellow to brown

SMILES

C#CCOCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.26%

SDS (393 KB)

COA (239 KB) HNMR (112 KB) GC (218 KB)

Handling Instructions (2659 KB)
References
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Propargyl-PEG4-alcohol Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-alcohol87450-10-0PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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Propargyl-PEG4-alcohol
Cat. No.:
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