1. PROTAC
  2. PROTAC Linkers
  3. Propargyl-PEG4-CH2COOH

Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG4-CH2COOH Chemical Structure

Propargyl-PEG4-CH2COOH Chemical Structure

CAS No. : 1429934-37-1

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50 mg USD 43 In-stock
100 mg USD 65 In-stock
250 mg USD 110 In-stock
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Description

Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

290.31

Formula

C13H22O7

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCOCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Propargyl-PEG4-CH2COOH
Cat. No.:
HY-140023
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