1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Propargyl-Tos

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-Tos Chemical Structure

Propargyl-Tos Chemical Structure

CAS No. : 23418-85-1

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Description

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

224.28

Formula

C11H12O3S

CAS No.
Appearance

Liquid (Density: 1.27 g/cm3)

Color

Colorless to light yellow

SMILES

C#CCCOS(C1=CC=C(C)C=C1)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.64%

References
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Product Name:
Propargyl-Tos
Cat. No.:
HY-79584
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