Propyl paraben-¹³C₆  (Synonyms: Propyl parahydroxybenzoate-¹³C₆; Propyl 4-hydroxybenzoate-¹³C₆)

Propyl paraben-¹³C₆ (Propyl parahydroxybenzoate-¹³C₆) is ¹³C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats^{[1][2][3][4][5][6][7]}.

186.16

C₄¹³C₆H₁₂O₃

2075718-26-0

94-13-3

[H][13C]1=[13C]([13C]([H])=[13C]([13C](C(OCCC)=O)=[13C]1[H])[H])O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. S Oishi, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002 Dec;40(12):1807-13.  [Content Brief]

  [3]. Gal A, et, al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106.  [Content Brief]

  [4]. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82.  [Content Brief]

  [5]. Ji X, et al. Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life Sci. 2004 Apr 30;74(24):3043-52.  [Content Brief]

  [6]. Yan W, et al. Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice. Ecotoxicol Environ Saf. 2022 Apr 15;235:113432.  [Content Brief]

  [7]. Gal A, et al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106.  [Content Brief]