Prostaglandin E2  (Synonyms: PGE2; Dinoprostone)

Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions^[1].

Prostaglandin E2 (GMP) (10 nM, supplemented in basic culture medium) blocks Paneth cell formation in cultured human small intestinal organoid (hSIO)^[1].
Prostaglandin E2 (GMP) (1 or 10 μM, 24 h ) increases proliferation of undifferentiated NE-4C stem cells^[2].
Prostaglandin E2 (GMP) (1 μM, 8 day) promotes the progression of NE-4C stem cell differentiation into neuronal-lineage cells^[2].
Prostaglandin E2 (GMP) (1 μM, 6 or 8 day) increases the expression of Cadherin-2 (neurosphere adhesion marker)^[2].
Prostaglandin E2 (GMP) (1 μM) enhances hematopoietic stem cells (HSCs) homing, survival, and proliferation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

352.47

C₂₀H₃₂O₅

363-24-6

Solid

White to off-white

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. He GW, et al. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell. 2022 Sep 1;29(9):1333-1345.e6.  [Content Brief]

  [2]. Wong CT, et al. Prostaglandin E2 promotes neural proliferation and differentiation and regulates Wnt target gene expression. J Neurosci Res. 2016 Aug;94(8):759-75.  [Content Brief]

  [3]. Hoggatt J, et al. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood. 2009 May 28;113(22):5444-55.  [Content Brief]