2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Proteasome
  4. PROTAC 20S proteasome subunit β5 degrader 2

PROTAC 20S proteasome subunit β5 degrader 2 

Cat. No.: HY-169135
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PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC50 of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models. (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

For research use only. We do not sell to patients.

PROTAC 20S proteasome subunit β5 degrader 2 Chemical Structure

PROTAC 20S proteasome subunit β5 degrader 2 Chemical Structure

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PROTAC 20S proteasome subunit β5 degrader 2 Related Antibodies

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Description

PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC50 of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models[1]. (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

Molecular Weight

845.74

Formula

C46H52BN5O10
SMILES

O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(NC4=CC=C(C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](B6O[C@@]7(C)[C@@H](C[C@H]8CC7O6)C8(C)C)CC(C)C)=O)=O)=O)=CC=C3)C2=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC 20S proteasome subunit β5 degrader 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC 20S proteasome subunit β5 degrader 2PROTACsProteasomeFaDumultiple myelomaneck squamous cell carcinomaInhibitorinhibitorinhibit

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