2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Androgen Receptor
  4. PROTAC AR Degrader-5

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein (HY-169967); black: linker (HY-169966); Blue: E3 ligase ligand (HY-125845)).

For research use only. We do not sell to patients.

PROTAC AR Degrader-5 Chemical Structure

PROTAC AR Degrader-5 Chemical Structure

CAS No. : 2703021-51-4

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PROTAC AR Degrader-5 Related Antibodies

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Description

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein (HY-169967); black: linker (HY-169966); Blue: E3 ligase ligand (HY-125845))[1].

In Vivo

PROTAC AR Degrader-5 (compound A46) (100, 200, 400, 800 µg + 12 µg TP; Skin application; daily for 21 days) inhibits sebaceous plaque in golden hamster[1].
PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 µL; Skin application; 2 times a day for 17 days) induces hair regeneration in C57BL/6N mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-8 weeks, 90-110g, Female Golden hamster[1]
Dosage: 100, 200, 400, 800 µg + 12 µg TP
Administration: Skin application; daily for 21 days
Result: Inhibited sebaceous plaque with the inhibition rate of 19.24%, 35.20%, 49.54%, 51.61% at 100, 200, 400, 800 µg, respectively.
Molecular Weight

1043.16

Formula

C52H54F4N8O7S2
CAS No.
SMILES

S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC AR Degrader-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AR Degrader-52703021-51-4PROTAC AR Degrader5PROTAC AR Degrader 5PROTACsAndrogen ReceptorInhibitorinhibitorinhibit

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