2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1.

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PROTAC BCR-ABL1 ligand 1 Chemical Structure

PROTAC BCR-ABL1 ligand 1 Chemical Structure

CAS No. : 2489876-34-6

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PROTAC BCR-ABL1 ligand 1 Related Antibodies

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Description

PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1].

In Vitro

GMB-475 (0-10 μM) exhibits cell proferation with IC50 values of 1.11,1.98,0.37 μM for BCR-ABL1 WT, T315I, G250E cells, respectively[1].
GMB-475 (0-30 μM) induces the degradation of BCR-ABL1 and c-ABL1 with concomitant inhibition of downstream signaling via the STAT5 pathway, in a dose- and time-dependent fashion in the context of both K562 and Ba/F3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BCR-ABL1 ligand 1 Related Antibodies

Western Blot Analysis[1]

Cell Line: K562 and Ba/F3 cells
Concentration: 0-30 μM
Incubation Time:
Result: Decreased p-STAT5 expression.
Molecular Weight

347.29

Formula

C17H12F3N3O2
CAS No.
SMILES

OC1=CC=C(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C=C1
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Purity & Documentation
References
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PROTAC BCR-ABL1 ligand 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BCR-ABL1 ligand 12489876-34-6Bcr-AblInhibitorinhibitorinhibit

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