2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRD4 Degrader-2

PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 14.2 nM against BRD4 BD1.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-2 Chemical Structure

PROTAC BRD4 Degrader-2 Chemical Structure

CAS No. : 2185795-53-1

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PROTAC BRD4 Degrader-2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 14.2 nM against BRD4 BD1[1].

IC50 & Target[1]

BRD4 BD1

14.2 nM (IC50)

Cereblon

 

Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
1.83 μM
Compound: 17
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
[PMID: 31813613]
In Vitro

PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC50 of 1.83±0.016 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BRD4 Degrader-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human monocyte lymphoma cell line THP-1
Concentration: 72 hours
Incubation Time: 0.81-3.26 μM
Result: Showd high anti-proliferative potency.
Molecular Weight

757.79

Formula

C40H39N9O7
CAS No.
SMILES

O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)COCCN4N=NC(CN5C(N(C)C6=C(C=C(C7=C(C)ON=C7C)C=C6)C5C8=CC=CC=C8)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRD4 Degrader-2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-22185795-53-1PROTACsEpigenetic Reader DomainApoptosisBRD4degraderproteindegradationmidlinecarcinomaacutemyeloidleukemiaprostatemultiple myelomabreastcancerHL-60Raji THP-1cellInhibitorinhibitorinhibit

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