1. PROTAC Epigenetics
  2. PROTACs Epigenetic Reader Domain
  3. PROTAC BRD4 Degrader-26

PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-26 Chemical Structure

PROTAC BRD4 Degrader-26 Chemical Structure

CAS No. : 3050769-37-1

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Description

PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))[1]

IC50 & Target

BRD4

 

Molecular Weight

965.43

Formula

C46H45ClN10O10S

CAS No.
SMILES

O=C(C1=C(NCCCOC2=CC(COC(NCCCNC(C[C@H]3C4=NN=C(C)N4C(SC(C)=C5C)=C5C(C6=CC=C(Cl)C=C6)=N3)=O)=O)=C([N+]([O-])=O)C=C2)C=CC=C17)N(C8C(NC(CC8)=O)=O)C7=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC BRD4 Degrader-26
Cat. No.:
HY-161650
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