2. PROTAC Apoptosis Autophagy
  3. Ligands for E3 Ligase Autophagy Apoptosis
  4. Thalidomide 4-fluoride

Thalidomide 4-fluoride  (Synonyms: Cereblon ligand 4; E3 ligase Ligand 4)

Cat. No.: HY-41547 Purity: 99.65%
SDS COA Handling Instructions

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Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

For research use only. We do not sell to patients.

Thalidomide 4-fluoride Chemical Structure

Thalidomide 4-fluoride Chemical Structure

CAS No. : 835616-60-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide 4-fluoride:

Thalidomide 4-fluoride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].

IC50 & Target

Cereblon

 

Molecular Weight

276.22

Formula

C13H9FN2O4
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (724.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6203 mL 18.1015 mL 36.2030 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.92%

SDS (393 KB)

COA (251 KB) HNMR (136 KB) RP-HPLC (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6203 mL 18.1015 mL 36.2030 mL 90.5076 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL 18.1015 mL
10 mM 0.3620 mL 1.8102 mL 3.6203 mL 9.0508 mL
15 mM 0.2414 mL 1.2068 mL 2.4135 mL 6.0338 mL
20 mM 0.1810 mL 0.9051 mL 1.8102 mL 4.5254 mL
25 mM 0.1448 mL 0.7241 mL 1.4481 mL 3.6203 mL
30 mM 0.1207 mL 0.6034 mL 1.2068 mL 3.0169 mL
40 mM 0.0905 mL 0.4525 mL 0.9051 mL 2.2627 mL
50 mM 0.0724 mL 0.3620 mL 0.7241 mL 1.8102 mL
60 mM 0.0603 mL 0.3017 mL 0.6034 mL 1.5085 mL
80 mM 0.0453 mL 0.2263 mL 0.4525 mL 1.1313 mL
100 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9051 mL
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Thalidomide 4-fluoride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide 4-fluoride835616-60-9Cereblon ligand 4 E3 ligase Ligand 4Cereblon ligand4Cereblon ligand-4Ligands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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