2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRM degrader-1

PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively.

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PROTAC BRM degrader-1 Chemical Structure

PROTAC BRM degrader-1 Chemical Structure

CAS No. : 2378051-80-8

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PROTAC BRM degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively[1].

IC50 & Target

PROTAC BRM degrader-1 (compound 17)[1] DC50：93 pM (BRM), 4.9 nM (BRG1)[1]
Molecular Weight

1068.29

Formula

C57H69N11O8S
CAS No.
SMILES

NC1=C(C=C(C(C=CC=C2)=C2O)N=N1)N3C[C@H](CC4)N(C5=CC=NC(O[C@@H](C6)C[C@H]6OC(CC7)CCN7CCOC8=NOC([C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)C)=O)=O)=C8)=C5)[C@H]4C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRM degrader-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRM degrader-12378051-80-8PROTAC BRM degrader1PROTAC BRM degrader 1PROTACsEpigenetic Reader DomaindegradePROTACInhibitorinhibitorinhibit

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