2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs FAK
  4. PROTAC FAK degrader 2

PROTAC FAK degrader 2 (Compound F2) is a PROTAC degrader for focal adhesion kinase (FAK), with DC50 of 27.72 and 60.1 nM, for total FAK and phosphorylated p-FAK. PROTAC FAK degrader 2 inhibits cell viability of cancer cells 4T1, MDA-MB-231, MDA-MB-468 and MDA-MB-435, with IC50s of 0.73-5.84 μM. PROTAC FAK degrader 2 reverses the multidrug resistance (MDR) through inhibition of AKT and ERK signaling pathway. PROTAC FAK degrader 2 exhibits antitumor efficacy in HCT/8 xenograft mouse model. (Pink: ligand for target protein Ifebemtinib (HY-122844); Black: linker (HY-Y0681); Blue: ligand for E3 ligase Thalidomide (HY-14658))

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PROTAC FAK degrader 2 Chemical Structure

PROTAC FAK degrader 2 Chemical Structure

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PROTAC FAK degrader 2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC FAK degrader 2 (Compound F2) is a PROTAC degrader for focal adhesion kinase (FAK), with DC50 of 27.72 and 60.1 nM, for total FAK and phosphorylated p-FAK. PROTAC FAK degrader 2 inhibits cell viability of cancer cells 4T1, MDA-MB-231, MDA-MB-468 and MDA-MB-435, with IC50s of 0.73-5.84 μM. PROTAC FAK degrader 2 reverses the multidrug resistance (MDR) through inhibition of AKT and ERK signaling pathway. PROTAC FAK degrader 2 exhibits antitumor efficacy in HCT/8 xenograft mouse model. (Pink: ligand for target protein Ifebemtinib (HY-122844); Black: linker (HY-Y0681); Blue: ligand for E3 ligase Thalidomide (HY-14658))[1]

Molecular Weight

927.90

Formula

C46H45F4N9O8
SMILES

COC1=CC(C(NC2CCN(CC2)CC3CCN(CC3)C4=CC5=C(C(N(C5=O)C6CCC(NC6=O)=O)=O)C=C4)=O)=C(C=C1NC7=NC(OC8=CC=CC9=C8C(N(C9)C)=O)=C(C=N7)C(F)(F)F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC FAK degrader 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC FAK degrader 2PROTAC FAK degrader2PROTAC FAK degrader-2PROTACsFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinase4T1MDA-MB-231MDA-MB-468MDA-MB-435HCT8/TA549/TMCF-7/ADRInhibitorinhibitorinhibit

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PROTAC FAK degrader 2
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