PROTAC Hemagglutinin Degrader-1

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PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity.

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PROTAC Hemagglutinin Degrader-1 Chemical Structure

CAS No. : 3031330-66-9

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Biological Activity
Purity & Documentation
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Description	PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity^[1].
In Vivo	PROTAC Hemagglutinin Degrader-1 (0-20 mg/kg; i.v.; daily for 5 days) protects mice against influenza A virus-induced toxic effects^[1]. PROTAC Hemagglutinin Degrader-1 displays a moderate oral bioavailability of approximately 6.8%^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1072.48
Formula	C₆₁H₉₃N₅O₉S
CAS No.	3031330-66-9
SMILES	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC8)C)([H])[C@]8(C)[C@@]6(CC4)C)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Li H, et al. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. J Med Chem. 2022 May 26;65(10):7154-7169. [Content Brief]