2. PROTAC
  3. PROTAC Linkers
  4. NH2-PEG5-C2-NH-Boc

NH2-PEG5-C2-NH-Boc  (Synonyms: PROTAC Linker 17)

Cat. No.: HY-W022240 Purity: ≥95.0%
SDS COA Handling Instructions

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NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG5-C2-NH-Boc Chemical Structure

NH2-PEG5-C2-NH-Boc Chemical Structure

CAS No. : 189209-27-6

Size Price Stock Quantity
100 mg USD 35 In-stock
500 mg USD 100 In-stock
1 g USD 160 In-stock
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10 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

NH2-PEG5-C2-NH-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG5-C2-NH-Boc Related Antibodies
Molecular Weight

380.48

Formula

C17H36N2O7
CAS No.
Appearance

Liquid (Density: 1.065±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)NCCOCCOCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (262.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6283 mL 13.1413 mL 26.2826 mL
5 mM 0.5257 mL 2.6283 mL 5.2565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (240 KB) HNMR (125 KB) MS (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6283 mL 13.1413 mL 26.2826 mL 65.7065 mL
5 mM 0.5257 mL 2.6283 mL 5.2565 mL 13.1413 mL
10 mM 0.2628 mL 1.3141 mL 2.6283 mL 6.5706 mL
15 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3804 mL
20 mM 0.1314 mL 0.6571 mL 1.3141 mL 3.2853 mL
25 mM 0.1051 mL 0.5257 mL 1.0513 mL 2.6283 mL
30 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
40 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
50 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3141 mL
60 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
80 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.8213 mL
100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
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NH2-PEG5-C2-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG5-C2-NH-Boc189209-27-6PROTAC Linker 17PROTAC Linker17PROTAC Linker-17PROTAC LinkersInhibitorinhibitorinhibit

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