2. PROTAC
  3. PROTAC Linkers
  4. NH2-C2-NH-Boc

NH2-C2-NH-Boc  (Synonyms: PROTAC Linker 22)

Cat. No.: HY-40171 Purity: 99.97%
COA Handling Instructions

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NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-C2-NH-Boc Chemical Structure

NH2-C2-NH-Boc Chemical Structure

CAS No. : 57260-73-8

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1 g USD 60 In-stock
5 g USD 150 In-stock
10 g USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of NH2-C2-NH-Boc:

NH2-C2-NH-Boc Related Antibodies

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Description

NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-C2-NH-Boc Related Antibodies
Molecular Weight

160.21

Formula

C7H16N2O2
CAS No.
Appearance

Liquid (Density: 1.012 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(NCCN)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (624.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2418 mL 31.2090 mL 62.4181 mL
5 mM 1.2484 mL 6.2418 mL 12.4836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.97%

COA (243 KB) HNMR (249 KB) RP-HPLC (213 KB) MS (80 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.2418 mL 31.2090 mL 62.4181 mL 156.0452 mL
5 mM 1.2484 mL 6.2418 mL 12.4836 mL 31.2090 mL
10 mM 0.6242 mL 3.1209 mL 6.2418 mL 15.6045 mL
15 mM 0.4161 mL 2.0806 mL 4.1612 mL 10.4030 mL
20 mM 0.3121 mL 1.5605 mL 3.1209 mL 7.8023 mL
25 mM 0.2497 mL 1.2484 mL 2.4967 mL 6.2418 mL
30 mM 0.2081 mL 1.0403 mL 2.0806 mL 5.2015 mL
40 mM 0.1560 mL 0.7802 mL 1.5605 mL 3.9011 mL
50 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1209 mL
60 mM 0.1040 mL 0.5202 mL 1.0403 mL 2.6008 mL
80 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9506 mL
100 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
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NH2-C2-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-C2-NH-Boc57260-73-8PROTAC Linker 22PROTAC Linker22PROTAC Linker-22PROTAC LinkersInhibitorinhibitorinhibit

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