2. Metabolic Enzyme/Protease PROTAC
  3. Phosphatase PROTACs
  4. PROTAC PTPN2 degrader-1

PROTAC PTPN2 degrader-1 (compound example 77) is a potent PTPN2 degrader. PROTAC PTPN2 degrader-1 has the potential for the research of cancer or metabolic disease.

For research use only. We do not sell to patients.

PROTAC PTPN2 degrader-1 Chemical Structure

PROTAC PTPN2 degrader-1 Chemical Structure

CAS No. : 2655638-07-4

Size Price Stock Quantity
1 mg USD 1000 In-stock
5 mg USD 2200 In-stock
10 mg USD 3420 In-stock
25 mg USD 6500 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

PROTAC PTPN2 degrader-1 Related Antibodies

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Description

PROTAC PTPN2 degrader-1 (compound example 77) is a potent PTPN2 degrader. PROTAC PTPN2 degrader-1 has the potential for the research of cancer or metabolic disease[1].

In Vitro

PROTAC PTPN2 degrader-1 (0-10 μM, 24 h) degrades PTPN2 in the 293T.109 (HiBiT-PTPN2) cell line, with 10 nM ≤ DC50 < 50 nM, Emax < 10 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC PTPN2 degrader-1 Related Antibodies
Molecular Weight

686.67

Formula

C33H27FN6O8S
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(CC1=CC=C(C2=CC(N(C)C(N3C4C(NC(CC4)=O)=O)=O)=C3C=C2)C=C1)NC5=CC6=CC(O)=C(N7CC(NS7(=O)=O)=O)C(F)=C6C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (145.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4563 mL 7.2815 mL 14.5630 mL
5 mM 0.2913 mL 1.4563 mL 2.9126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4563 mL 7.2815 mL 14.5630 mL 36.4076 mL
5 mM 0.2913 mL 1.4563 mL 2.9126 mL 7.2815 mL
10 mM 0.1456 mL 0.7282 mL 1.4563 mL 3.6408 mL
15 mM 0.0971 mL 0.4854 mL 0.9709 mL 2.4272 mL
20 mM 0.0728 mL 0.3641 mL 0.7282 mL 1.8204 mL
25 mM 0.0583 mL 0.2913 mL 0.5825 mL 1.4563 mL
30 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2136 mL
40 mM 0.0364 mL 0.1820 mL 0.3641 mL 0.9102 mL
50 mM 0.0291 mL 0.1456 mL 0.2913 mL 0.7282 mL
60 mM 0.0243 mL 0.1214 mL 0.2427 mL 0.6068 mL
80 mM 0.0182 mL 0.0910 mL 0.1820 mL 0.4551 mL
100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.3641 mL
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PROTAC PTPN2 degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC PTPN2 degrader-12655638-07-4PhosphatasePROTACsAnti-tumorPTPN2Inhibitorinhibitorinhibit

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