2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2/4-degrader-10

PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)).

For research use only. We do not sell to patients.

PROTAC SMARCA2/4-degrader-10 Chemical Structure

PROTAC SMARCA2/4-degrader-10 Chemical Structure

CAS No. : 2568277-33-6

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PROTAC SMARCA2/4-degrader-10 Related Antibodies

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Description

PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845))[1].

In Vitro

PROTAC SMARCA2/4-degrader-10 (compound I-399) (0-1000 nM; 24 h) induces SMARCA2, SMARCA4 protein degradation in MV4-11 cells with DC50 values of <100, <100 nM for SMARCA2, SMARCA4, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SMARCA2/4-degrader-10 Related Antibodies
Molecular Weight

903.15

Formula

C49H62N10O5S
CAS No.
SMILES

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)C3=CN(C4CCN(CC4)CC[C@@H]5CC[C@H](CC5)C(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)N=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2/4-degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4-degrader-102568277-33-6PROTACsEpigenetic Reader DomainA549 cellsSMARCA2SMARCA4cancerInhibitorinhibitorinhibit

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