1. PROTAC Epigenetics
  2. PROTACs Epigenetic Reader Domain
  3. PROTAC SMARCA2/4-degrader-20

PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))

For research use only. We do not sell to patients.

PROTAC SMARCA2/4-degrader-20 Chemical Structure

PROTAC SMARCA2/4-degrader-20 Chemical Structure

CAS No. : 2568277-38-1

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Description

PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))[1]

Molecular Weight

998.13

Formula

C50H58F3N11O6S

CAS No.
SMILES

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)OC(F)(F)F)=O)=O)=O)C=N5)C(CC4)C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PROTAC SMARCA2/4-degrader-20
Cat. No.:
HY-163873
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