2. PROTAC Epigenetics
  3. Epigenetic Reader Domain PROTACs
  4. PROTAC SMARCA2/4-degrader-25

PROTAC SMARCA2/4-degrader-25 is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248), PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140), and target protein ligand SMARCA2/4-ligand-3 (HY-162814), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845).

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PROTAC SMARCA2/4-degrader-25 Chemical Structure

PROTAC SMARCA2/4-degrader-25 Chemical Structure

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PROTAC SMARCA2/4-degrader-25 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2/4-degrader-25 is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248), PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140), and target protein ligand SMARCA2/4-ligand-3 (HY-162814), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845)[1].

IC50 & Target

SMARCA2/4[1]
Molecular Weight

927.06

Formula

C44H50N10O9S2
SMILES

O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC=C2C3=NN=C(N)C(N4CCN(CC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)CC4)=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC SMARCA2/4-degrader-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4-degrader-25Epigenetic Reader DomainPROTACsInhibitorinhibitorinhibit

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