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  4. PROTAC SMARCA2 degrader-10

PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.

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PROTAC SMARCA2 degrader-10 Chemical Structure

PROTAC SMARCA2 degrader-10 Chemical Structure

CAS No. : 2568279-34-3

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PROTAC SMARCA2 degrader-10 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

IC50 & Target

SMARCA2[1]
Molecular Weight

973.19

Formula

C55H60N10O5S
CAS No.
SMILES

O=C(C1=CC=C(C2=CC=C(C=C2)CN3CCC(CC3)CN4C=C(C5=C(N)N=NC(C6=C(C=CC=C6)O)=C5)C=N4)C=C1)N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-102568279-34-3PROTACsInhibitorinhibitorinhibit

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