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SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.

For research use only. We do not sell to patients.

PROTAC SMARCA2 degrader-14 Chemical Structure

PROTAC SMARCA2 degrader-14 Chemical Structure

CAS No. : 2568276-73-1

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Description

SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

IC50 & Target

SMARCA2[1]

Molecular Weight

689.76

Formula

C37H39N9O5

CAS No.
SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(NC4CCC(CC4)N5CCC(CC5)N6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C3C2=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PROTAC SMARCA2 degrader-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC SMARCA2 degrader-14
Cat. No.:
HY-163866
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