2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2 degrader-21

PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <1 nM and >100 nM, respectively.

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PROTAC SMARCA2 degrader-21 Chemical Structure

PROTAC SMARCA2 degrader-21 Chemical Structure

CAS No. : 2891464-61-0

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PROTAC SMARCA2 degrader-21 Related Antibodies

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Description

PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <1 nM and >100 nM, respectively[1].

Molecular Weight

995.24

Formula

C54H66N12O5S
CAS No.
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4CC5(CC(C5)N6CCC(CC6)C7=NC(N8CCN9C%10=CC(C%11=C(C=CC=C%11)O)=NN=C%10NC[C@H]9C8)=NC=C7)C4)=O)=O)O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-21 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-212891464-61-0PROTACsEpigenetic Reader DomainA549MV411Inhibitorinhibitorinhibit

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