2. Epigenetics PROTAC
  3. Epigenetic Reader Domain PROTACs
  4. PROTAC SMARCA2 degrader-29

PROTAC SMARCA2 degrader-29 (Example 87) is a PROTAC SMARCA2 (BRM) degrader, with DC50 of 10-100 nM (BRM) and > 1 μM (BRG1, also known as SMARCA2) respectively.

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PROTAC SMARCA2 degrader-29 Chemical Structure

PROTAC SMARCA2 degrader-29 Chemical Structure

CAS No. : 2865193-25-3

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PROTAC SMARCA2 degrader-29 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2 degrader-29 (Example 87) is a PROTAC SMARCA2 (BRM) degrader, with DC50 of 10-100 nM (BRM) and > 1 μM (BRG1, also known as SMARCA2) respectively[1].

Molecular Weight

875.11

Formula

C47H54N8O5S2
CAS No.
SMILES

CC(C)[C@@H](C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)C4=CC(N5CCC(N6CCC(C7=CC8=C(C=C(C9=CC=CC=C9O)N=N8)S7)CC6)CC5)=NO4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-29 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-292865193-25-3Epigenetic Reader DomainPROTACsInhibitorinhibitorinhibit

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