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  4. PROTAC SMARCA2 degrader-6

PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.

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PROTAC SMARCA2 degrader-6 Chemical Structure

PROTAC SMARCA2 degrader-6 Chemical Structure

CAS No. : 2568523-72-6

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PROTAC SMARCA2 degrader-6 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

IC50 & Target

SMARCA2[1]
Molecular Weight

1023.30

Formula

C56H70N12O5S
CAS No.
SMILES

O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC([C@H]2C[C@]3(C[C@H](CN4CCC(CC4)C5=CN=C(N6C7CN(CC6CC7)C8=C(N)N=NC(C9=CC=CC=C9O)=C8)N=C5)C3)C2)=O)C(C)(C)C)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-62568523-72-6PROTACsInhibitorinhibitorinhibit

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