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  4. PROTAC SMARCA2 degrader-8

PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells.

For research use only. We do not sell to patients.

PROTAC SMARCA2 degrader-8 Chemical Structure

PROTAC SMARCA2 degrader-8 Chemical Structure

CAS No. : 2669027-50-1

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PROTAC SMARCA2 degrader-8 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells[1].

Molecular Weight

818.99

Formula

C43H50N10O5S
CAS No.
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C4=CC=NC(N5CCN(C6=CC(C7=CC=CC=C7O)=NN=C6N)CC5)=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-8 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-82669027-50-1PROTACsSMARCA2 degraderPROTACA375Inhibitorinhibitorinhibit

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PROTAC SMARCA2 degrader-8
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