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  4. PROTAC SMARCA2 degrader-9

PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.

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PROTAC SMARCA2 degrader-9 Chemical Structure

PROTAC SMARCA2 degrader-9 Chemical Structure

CAS No. : 2568276-39-9

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PROTAC SMARCA2 degrader-9 Related Antibodies

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Description

PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

IC50 & Target

SMARCA2[1]
Molecular Weight

758.87

Formula

C40H46N12O4
CAS No.
SMILES

OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(N6CCN(CCCC7=CC(N(C)C(N8C9CCC(NC9=O)=O)=O)=C8C=C7)CC6)C=N5)C3)=C(N)N=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-92568276-39-9PROTACsInhibitorinhibitorinhibit

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