2. PROTAC MAPK/ERK Pathway GPCR/G Protein
  3. PROTACs Ras
  4. PROTAC SOS1 degrader-1 TFA

PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity.

For research use only. We do not sell to patients.

PROTAC SOS1 degrader-1 TFA Chemical Structure

PROTAC SOS1 degrader-1 TFA Chemical Structure

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1 mg USD 550 In-stock
5 mg USD 1150 In-stock
10 mg USD 1850 In-stock
25 mg USD 3330 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC SOS1 degrader-1 TFA:

PROTAC SOS1 degrader-1 TFA Related Antibodies

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  • Purity & Documentation

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Description

PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity[1].

IC50 & Target

DC50: 98.4 nM (SOS1)[1]
Molecular Weight

1165.82

Formula

C59H77ClF4N10O6S
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCN2CCN(C3=C4C(N(CC5=CC(C)=C(F)C(C)=C5)C(N6CC7(CNC7)C6)=N4)=CC(Cl)=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (85.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8578 mL 4.2888 mL 8.5777 mL
5 mM 0.1716 mL 0.8578 mL 1.7155 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8578 mL 4.2888 mL 8.5777 mL 21.4441 mL
5 mM 0.1716 mL 0.8578 mL 1.7155 mL 4.2888 mL
10 mM 0.0858 mL 0.4289 mL 0.8578 mL 2.1444 mL
15 mM 0.0572 mL 0.2859 mL 0.5718 mL 1.4296 mL
20 mM 0.0429 mL 0.2144 mL 0.4289 mL 1.0722 mL
25 mM 0.0343 mL 0.1716 mL 0.3431 mL 0.8578 mL
30 mM 0.0286 mL 0.1430 mL 0.2859 mL 0.7148 mL
40 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5361 mL
50 mM 0.0172 mL 0.0858 mL 0.1716 mL 0.4289 mL
60 mM 0.0143 mL 0.0715 mL 0.1430 mL 0.3574 mL
80 mM 0.0107 mL 0.0536 mL 0.1072 mL 0.2681 mL
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PROTAC SOS1 degrader-1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SOS1 degrader-1PROTACsRaslow toxicityanti-tumorNCI-H358 cellsanti-proliferationKRAS-GTPpERKxenografts modelKRAS MutationsInhibitorinhibitorinhibit

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