2. PROTAC MAPK/ERK Pathway GPCR/G Protein
  3. PROTACs Ras
  4. PROTAC SOS1 degrader-5

PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM.

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PROTAC SOS1 degrader-5 Chemical Structure

PROTAC SOS1 degrader-5 Chemical Structure

CAS No. : 2836273-61-9

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PROTAC SOS1 degrader-5 Related Antibodies

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Description

PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM[1].

Molecular Weight

872.93

Formula

C45H51F3N8O7
CAS No.
SMILES

CC1=NC2=C(C=C(C(OC)=C2)OCC3(CN(C(CCCCCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)C)CC3)C(N[C@@H](C7=CC(N)=CC(C(F)(F)F)=C7)C)=N1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SOS1 degrader-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SOS1 degrader-52836273-61-9PROTACsRasPROTAC SOS1 degraderubiquitin-proteasome systemKRASNCI-H358Inhibitorinhibitorinhibit

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