2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs VEGFR
  4. PROTAC VEGFR-2 degrader-2

PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM).

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PROTAC VEGFR-2 degrader-2 Chemical Structure

PROTAC VEGFR-2 degrader-2 Chemical Structure

CAS No. : 2353417-85-1

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PROTAC VEGFR-2 degrader-2 Related Antibodies

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Description

PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM)[1].

Cellular Effect
Cell Line Type Value Description References
EA.hy 926 IC50
133.248 μM
Compound: PROTAC-4
Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
[PMID: 32750566]
Molecular Weight

930.10

Formula

C50H56FN9O6S
CAS No.
SMILES

CC1=CC=C(C(NC(NC2=CC=C(C=C2)C3=CC=CC4=C3C(N)=NN4C(CCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC VEGFR-2 degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC VEGFR-2 degrader-22353417-85-1PROTACsVEGFRVascular endothelial growth factor receptorAnti-angiogenesis agentsVascular normalizationPROTAC VEGFR2 degraderInhibitorinhibitorinhibit

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PROTAC VEGFR-2 degrader-2
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