2. Cell Cycle/DNA Damage PROTAC
  3. DNA/RNA Synthesis PROTACs
  4. PROTAC WDR5 degrader 1

PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).

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PROTAC WDR5 degrader 1 Chemical Structure

PROTAC WDR5 degrader 1 Chemical Structure

CAS No. : 2737222-94-3

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PROTAC WDR5 degrader 1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A)[1].

IC50 & Target

WDR5[1]
Molecular Weight

1012.15

Formula

C52H60F3N9O7S
CAS No.
SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3CCN(CC3)C)C=CC(C4=CC=C(C=C4)C(NCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC WDR5 degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC WDR5 degrader 12737222-94-3DNA/RNA SynthesisPROTACsInhibitorinhibitorinhibit

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