2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Proteasome-IN-7

Proteasome-IN-7 (Compound 6f) is an epoxyketone macrocyclic peptidyl proteasome inhibitor (IC50 value of 37.92 nM for 20S proteasome ChT-L subunit). Proteasome-IN-7 displays robust antiproliferative effects against multiple myeloma, acute lymphoblastic leukemia and non-small cell lung cancer.

For research use only. We do not sell to patients.

Proteasome-IN-7 Chemical Structure

Proteasome-IN-7 Chemical Structure

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Proteasome-IN-7 Related Antibodies

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Description

Proteasome-IN-7 (Compound 6f) is an epoxyketone macrocyclic peptidyl proteasome inhibitor (IC50 value of 37.92 nM for 20S proteasome ChT-L subunit). Proteasome-IN-7 displays robust antiproliferative effects against multiple myeloma, acute lymphoblastic leukemia and non-small cell lung cancer[1].

IC50 & Target

IC50 value of 37.92 nM for 20S proteasome ChT-L subunit
Molecular Weight

909.06

Formula

C48H56N6O10S
SMILES

COC(/C=C(C1=C2C=CC=CC2=C3SC[C@H](NC([C@@H](NC([C@H](CCCCN31)NC(C4=CC=CN=C4)=O)=O)CCC5=CC=CC=C5)=O)C(N[C@H](C([C@]6(CO6)C)=O)CC(C)C)=O)\C(OC)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Proteasome-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proteasome-IN-7ProteasomeAntiproliferativeRPMI-8226RS4;11MV-4-11 and NCI-H1299.Inhibitorinhibitorinhibit

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