2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Angiopoietins
  5. Angiopoietin Like 4

Angiopoietin Like 4

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Angiopoietin-like proteins (ANGPTLs) are identified as a family of proteins structurally similar to the angiopoietins. Eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. ANGPTLs do not bind to the receptors classically targeted by angiopoietins, Tie-1/2, and have been generally considered orphan ligands. Similar to angiopoietins, ANGPTLs are able to potently regulate angiogenesis.
Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. For example, ANGPTL 2, 3, 4, 6 and 7 are pro-inflammatory factors and regulate cancer progression, while ANGPTL1 inhibits tumor angiogenesis and metastasis.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7508
    ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, Fc, solution)

    rMuAngiopoietin-Related Protein 4, C-Fc; ANGPTL4; Angiopoietin-Related Protein 4

    		Mouse HEK293
    Angiopoietin-related protein 4/ANGPTL4 Protein, Mouse (HEK293, Fc) expresses in HEK293 with an Fc fragment at the C-terminus. Angiopoietin-Related Protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation.
  • HY-P7507
    ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)

    rHuAngiopoietin-Related Protein 4, His; ANGPTL4; Angiopoietin-Related Protein 4

    		Human HEK293
    Angiopoietin-like protein 4, Human modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). Angiopoietin-Related Protein 4 is a conventional, non-competitive inhibitor that binds to LPL to prevent the hydrolysis of substrate as part of reversible mechanism.
  • HY-P700655
    ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His)

    ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4;

    		Cynomolgus HEK293
    ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is 243 a.a., with molecular weight of 35-40 kDa.
  • HY-P7508A
    ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, hFc)

    rMuAngiopoietin-Related Protein 4, C-Fc; ANGPTL4; Angiopoietin-Related Protein 4

    		Mouse HEK293
    Angiopoietin-related protein 4/ANGPTL4 Protein, Mouse (HEK293, Fc) expresses in HEK293 with an Fc fragment at the C-terminus. Angiopoietin-Related Protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation.
  • HY-P78237
    ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His)

    ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4; Angiopoietin-3; ANGPT4; MGC138181; MGC138183

    		Mouse HEK293
    ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 35-50 kDa.
  • HY-P700562
    ANGPTL4/Angiopoietin-related 4 Protein, Human (GST)

    Angiopoietin-like protein 4Hepatic fibrinogen/angiopoietin-related protein ; HFARP

    		Human E. coli
    ANGPTL4 protein mediates lipoprotein lipase (LPL) inactivation, regulating triglyceride clearance and lipid metabolism. It also affects glucose homeostasis, insulin sensitivity, endothelial cell function, and angiogenesis. Cleaved ANGPTL4 is more active in LPL inactivation, highlighting its multifaceted role in metabolic and vascular regulation. ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) is the recombinant human-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by E. coli , with N-GST labeled tag.
Cat. No. Product Name Effect Purity