2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. TGF-alpha

TGF-alpha

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Transforming growth factor α (TGF-alpha; TGF-α) is a mitogenic polypeptide member of the epidermal growth factor (EGF) family of cytokines. TGF-α is composed of 50 amino acids, and displays 35-40% homology with EGF which is the prototypic member of the EGF superfamily. Like EGF, TGF-α is also a ligand of epidermal growth factor receptor (EGFR). TGF-α binds to the EGFR to stimulate an intact RAS/RAF/MAPK pathway, leading to the transcription of genes associated with cell proliferation, invasion and metastasis.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P700149AF
    Animal-Free TGF alpha/TGFA Protein, Human (His)

    ETGF; TGF-alpha; TGF type 1; TGFA

    		Human E. coli
    TGF α/TGFA protein is a mitogenic polypeptide that binds to EGFR and acts synergistically with TGF β to promote anchorage-dependent cell proliferation. Its interaction with MAGI3, SDCBP, and the SNTA1 PDZ domain, especially with SDCBP, is critical for efficient cell surface targeting. Animal-Free TGF alpha/TGFA Protein, Human (His) is the recombinant human-derived animal-FreeTGF alpha/TGFA protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free TGF alpha/TGFA Protein, Human (His) is 50 a.a., with molecular weight of ~6.49 kDa.
  • HY-P7296
    TGF alpha/TGFA Protein, Human (CHO)

    rHuTGF-α; ETGF; TGFA

    		Human CHO
    TGF-alpha Protein, Human (CHO) is a potent angiogenic mediator and mitogenic polypeptide.
  • HY-P7411
    TGF alpha/TGFA Protein, Human

    rHuTGF-α; ETGF; TGF-type I

    		Human E. coli
    TGF-alpha Protein, Human is a 50-amino-acid polypeptide that binds to the epidermal growth factor (EGF) receptor and stimulates cell growth.
  • HY-P77857
    TGF alpha/TGFA Protein, Mouse (HEK293, Fc)

    ETGF; TGF-alpha; TGF type 1; TGFA

    		Mouse HEK293
    TGF α/TGFA is a mitogenic peptide that binds to the EGF receptor (EGFR) and acts synergistically with TGF β to achieve anchorage-independent cell proliferation in soft agar.It interacts with SDCBP and the SNTA1 PDZ domain, which is critical for cell surface localization.TGF alpha/TGFA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TGF alpha/TGFA protein, expressed by HEK293 , with N-hFc labeled tag.
Cat. No. Product Name Effect Purity